Been drawing for about ~5 hours now on the new app, have recorded at least 3-4 crashes per hour, once up to six crashes in an hour. This is driving me NUTS. Every time it crashes I lose my current brush settings, color settings, and a decent chunk of progress. I have autosave configured to every 5 minutes and I crash every ~15 minutes. I work with fairly huge files, some of which take up to ~30 seconds to save and sometimes freezes while (auto)saving. Also, the zoom lag seems to be much more apparent in the new update than previously noted.
EDIT, IMPORTANT EDIT:: My favorites panel isn't saving between crashes. Every single time I've had to edit my brush settings after a few minutes of drawing, realizing I'm using bad settings.
Additional edit: 80% of the crashes happen when I'm adjusting brush settings, most usually by the sliders. The remaining 20 or so happen randomly when the app is idle, usually when I'm taking a moment to check something on my computer.
Edit again: Just recorded three crashes in a seventeen minute period. There wasn't enough time between the crashes to save ANY progress.